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48 extending up to 96 weeks, the proportion of patients who developed Grade 2-4 ALT and/or AST elevations increased from 26% at week 48 to 32. ,
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Patients should be individually titrated to the lowest dose that is sufficient for sexual intercourse. ,
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The plasma levels of clarithromycin and 14-hydroxy-clarithromycin were increased by the concomitant administration of omeprazole. ,
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